Focused Ultrasound for Neuromodulation
نویسندگان
چکیده
منابع مشابه
Neuromodulation accompanying focused ultrasound-induced blood-brain barrier opening
Burst-mode focused ultrasound (FUS) induces microbubble cavitation in the vasculature and temporarily disrupts the blood-brain barrier (BBB) to enable therapeutic agent delivery. However, it remains unclear whether FUS-induced BBB opening is accompanied by neuromodulation. Here we characterized the functional effects of FUS-induced BBB opening by measuring changes in somatosensory evoked potent...
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Transcranial ultrasound can alter brain function transiently and nondestructively, offering a new tool to study brain function now and inform future therapies. Previous research on neuromodulation implemented pulsed low-frequency (250-700 kHz) ultrasound with spatial peak temporal average intensities (ISPTA) of 0.1-10 W/cm(2). That work used transducers that either insonified relatively large v...
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Analysis of Transcranial Focused Ultrasound Beam Profile Sensitivity for Neuromodulation of the Human Brain Jerel K. Mueller, Wynn Legon, and William J. Tyler* 1 School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 2 Dept. of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN 3 School of Biological and Health Systems Engineering, Arizona State...
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Background/introduction Temporal lobe epilepsy (TLE) is the most common pharmacologically refractory form of epilepsy. While it can often be effectively treated by temporal lobe surgery, that does not always eliminate seizures, and many patients are not suitable candidates for surgery. A noninvasive method to augment surgical or medical treatment of TLE would be highly useful. Low-intensity foc...
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Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Toward this goal, we have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug, in this case the small molecule anesthetic propofol, upon the application of focused ultrasound. These nanoparticles are composed of biodegradable an...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2018
ISSN: 1933-7213,1878-7479
DOI: 10.1007/s13311-018-00691-3